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For significant differences, the difference between the two groups' averages would be large and its corresponding p-value would be small

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Whereas carbon monoxide may have a similar anti-inflammatory profile to exercise 123 and nicotine induces inhibition of microglia and reduces TNF- activation through the activation of the 7 nicotinic acetylcholine receptor (nAChR) 22,124,125,126,127,128 , tobacco exposure exerts acute pro-inflammatory effects by inducing the production of IL-1 and TNF- 129,130

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Some of these methods may also open up the airways, improve lung capacity, and reduce inflammation, which can help reduce the effects of pollution and smoke in the lungs

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